Clomifene is one of several alternatives for ovulation induction in those who are infertile due to anovulation or oligoovulation. Evidence is lacking for the use of clomifene in those who are infertile without a known reason. In such cases, studies have observed a clinical pregnancy rate 5. 6% per cycle with clomifene treatment vs. 1. 3%–4. 2% per cycle without treatment.
Ovulation Induction: Clomiphene citrate is used to induce ovulation in women who have infertility caused by anovulation or irregular ovulation. It works by blocking estrogen receptors in the hypothalamus, which leads to an increase in follicle-stimulating hormone (FSH) and luteinizing hormone (LH) release from the pituitary gland. This stimulates the development and release of eggs from the ovaries.
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